influence of dietary protein content on trypanosoma cruzi infection in germfree and conventional mice

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ID: 220901
1998
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Abstract
Germfree (GF) and conventional (CV) mice were fed on diets containing 4.4, 13.2 or 26.4% of protein (weight/weight). CV mice fed on low protein diet did not gain weight during four weeks, whereas the protein deficient diet did not affect the growth of GF mice. After four weeks on these diets, the mice were inoculated with 5x103 trypomastigotes of Trypanosoma cruzi. The protein deficiency affected less the GF than the CV mice, according to the following parameters: weight gain, hemoglobin, plasma protein and albumin levels and water and protein contents of the carcass. Infection with T. cruzi produced a significant decrease in hemoglobin levels, red blood cell count, and water and protein contents in the carcass. This decrease was more pronounced in the GF mice. Histopathologically, there was no difference between the treatments in animals with the same microbiological status (GF or CV). However, the disease was more severe in the GF than in the CV mice.
Camundongos isentos de germes (GF) e convencionais (CV) foram alimentados com rações contendo 4,4, 13,2 ou 26,4% de proteína (peso/peso). Os camundongos CV alimentados com ração baixa em proteína não ganharam peso durante quatro semanas, enquanto a ração deficiente em proteína não afetou o crescimento dos camundongos GF. Após quatro semanas nessas rações, os camundongos foram inoculados com 5x103 tripomastigotos de Trypanosoma cruzi. A deficiência em proteína afetou menos os camundongos GF do que os CV, segundo os seguintes parâmetros: ganho em peso, hemoglobina, níveis em proteína e albumina no plasma e conteúdos em água e proteína na carcassa. A infecção com T. cruzi produziu um decréscimo significante nos níveis em hemoglobina, na contagem de células vermelhas sanguíneas e nos conteúdos em água e proteína na carcassa. Este descréscimo foi mais acentuado nos camundongos GF. Histopatologicamente, não houve diferença entre os tratamentos nos animais com o mesmo estatuto microbiológico (GF ou CV). Contudo, a doença foi mais grave nos camundongos GF do que nos CV.
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Authors ;Isa P. CINTRA;Marcelo E. SILVA;Marcílio E.C. SILVA;Márcio E. SILVA;L.C. C. AFONSO;Jacques R. NICOLI;Eduardo A. BAMBIRRA;Enio C. VIEIRA
Journal 2017 12th international conference for internet technology and secured transactions, icitst 2017
Year 1998
DOI
10.1590/S0036-46651998000600004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000600004
Keywords
american trypanosomiasis tropical medicine trypanosoma cruziarctic medicine

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