a new urease inhibitor from viola betonicifolia

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ID: 220798
2014
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Abstract
Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.
Reference Key
muhammad2014moleculesa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Naveed Muhammad;Muhammad Saeed;Ajmal Khan;Achyut Adhikari;Abdul Wadood;Khalid Mohammed Khan;Vincenzo De Feo
Journal Journal of ethnopharmacology
Year 2014
DOI
10.3390/molecules191016770
URL
http://www.mdpi.com/1420-3049/19/10/16770
Keywords
kinetic study urease inhibition viola betonicifolia

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