effects of temperature and wavelength choice on in-situ dissolution test of cimetidine tablets
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ID: 220722
2013
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Abstract
The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)<1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of λmax (218 nm) was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature (37° C) with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets. Keywords: Cimetidine tablets, Drug dissolution test, In-situ dissolution test, UVâvis
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li2013journaleffects
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| Authors | ;Xin-Xia Li;Yan Wang;Ping-Ping Xu;Qi-Zhou Zhang;Kun Nie;Xu Hu;Bin Kong;Li Li;Jian Chen |
| Journal | Frontiers in plant science |
| Year | 2013 |
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