seven challenges in modeling pathogen dynamics within-host and across scales
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2015
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Abstract
The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.
| Reference Key |
gog2015epidemicsseven
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|---|---|
| Authors | ;Julia R. Gog;Lorenzo Pellis;James L.N. Wood;Angela R. McLean;Nimalan Arinaminpathy;James O. Lloyd-Smith |
| Journal | Communications biology |
| Year | 2015 |
| DOI |
10.1016/j.epidem.2014.09.009
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