a1at polymorphisms may be associated with clinical characteristics of retrovirus infections in a mixed ethnic population from the brazilian amazon region

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ID: 220080
2017
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Abstract
Objectives: This study investigated the association of alpha-1-antrypsin deficiency (A1AT; S and Z polymorphisms) with HIV-1 and HTLV-1 infection. Methods: Blood samples from 201 HIV-1-infected and 115 HTLV-1-infected individuals were examined and compared with those from 300 healthy controls. Genotyping of A1AT (S and Z) and quantification of plasma viral load were performed using RT-PCR, and the CD4+/CD8+ T-cell count was determined by flow cytometry. Results: The wild-type MM genotype showed the highest frequency in each of the three groups investigated. SS and ZZ homozygous genotypes (variants) were observed only among HTLV-1 patients and controls, respectively. Genotype MS was significantly less frequent in HTLV-1-positive persons than in controls. Statistically significant differences were observed when comparing genotype frequencies between symptomatic and asymptomatic HTLV-1-infected persons. The distribution of plasma HIV-1 viral load among individuals with different genotypes of A1AT polymorphism also differed significantly. Conclusions: The results suggest that A1AT polymorphisms may be associated with human retrovirus infections when dealing with an ethnically mixed population from the Amazon region of Brazil. Keywords: A1T1, Polymorphisms, HIV-1, HTLV-1
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ferreira2017internationala1at Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thalita Camêlo da Silva Ferreira, Maria Alice Freitas Queiroz, Gustavo Adolfo Argañaraz, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Enrique Roberto Argañaraz
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Journal israel journal of chemistry
Year 2017
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1201971217302539
Keywords
Infectious and parasitic diseases

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