a convenient new synthesis, characterization and antibacterial activity of double headed acyclo-c-nucleosides from unprotected d-glucose

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ID: 219035
2016
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Abstract
Double headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-tetrol (6), 5,5′-(1,2,3,4-tetrahydroxybutane-1,4-diyl)bis(1,3,4-oxadiazole-2(3H)-thione) (7), and 1,4-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)butane-1,2,3,4-tetrol (8) have been synthesized from d-glucose (1) without protecting hydroxyl groups. Two steps synthesis leading to formation of 2,3,4,5-tetrahydroxyhexanedihydrazide (4) which is regarded as starting intermediates for the synthesis of 6,7 and 8. Synthetic intermediates and final products were appropriately characterized by IR, 1H NMR and 13C NMR. The products were tested in vitro against gram positive bacteria Staphylococcus aureus, Listeria inovanii and gram negative bacteria Klebsiella pneumoniae, Salmonella sp., Escherichia coli and compared with the known antibiotic: amoxicillin + clavulanic acid (AMC) and showed variable effects.
Reference Key
amara2016arabiana Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sarah Amara;Adil A. Othman
Journal Behavioural brain research
Year 2016
DOI
10.1016/j.arabjc.2012.05.005
URL
http://www.sciencedirect.com/science/article/pii/S1878535212001372
Keywords
3 2 1 4-triazole antibacterial activitychemistry

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