synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

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ID: 219031
2015
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Abstract
An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
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Authors ;Wen-Chang Chen;Veerababurao Kavala;Yu-Hsuan Shih;Yu-Hsuan Wang;Chun-Wei Kuo;Tang-Hao Yang;Chia-Yu Huang;Hao-Hsiang Chiu;Ching-Fa Yao
Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules200610910
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