optimization of a hplc procedure for simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxoplatinum(iv) in aqueous solutions

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ID: 218003
2011
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Abstract
A RP-HPLC procedure for the simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxo-platinum(IV), was development. The developed procedure was validated in terms of linearity, accuracy, precision, limits of detection (LOD), limits of quantification (LOQ) and specificity. The limits of detection (LOD) were 0.47 x 10-4 and 0.53 x 10-4 mol L-1 and the limits of quantification (LOQ) were 1.57 x 10-4 and 1.75 x 10-4 mol L-1, for cisplatin and cis,cis,trans-diamminedichlorodihydroxopla-tinum(IV), respectively. The average recoveries of cisplatin and cis,cis,trans-diamminedichlorodihydroxoplatinum(IV) was 100.6% ± 1.4 and 101.2% ± 1.1, respectively. Intermediate (inter-day) precision, repeatability and specificity of the procedure for hydrolysis products of cisplatin were studied. The results of the study showed that the proposed RP-HPLC procedure is simple, rapid, precise, accurate and specific.
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ramos2011qumicaoptimization Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yalexmi Ramos, Carlos Hernández, Lidia Asela Fernandez, Mayra Bataller, Eliet Veliz, Renny Small
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Journal greece and rome
Year 2011
DOI
10.1590/S0100-40422011000800026
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800026&lng=en&tlng=en
Keywords
cis cisplatin

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