Polyethylenimine and sodium cholate-modified ethosomes complex as multidrug carrier for the treatment of melanoma through transdermal delivery.

Clicks: 341
ID: 21784
2019
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Abstract
Multidrug resistance is the main reason for the failure of chemotherapy during the treatment of the tumor. To overcome multidrug resistance, this study attempts to develop a novel transdermal drug-delivery system (TDDS) loading cytotoxic drug and chemosensitizer. The polyethylenimine-modified ethosomes (Eth) and sodium cholate-modified ethosomes (Eth) were firstly fabricated, and then a novel TDDS based on the carriers complex of Eth/Eth was prepared by electrostatic interaction and evaluated both and . The Eth/Eth showed the excellent antitumor effect on treating melanoma, using doxorubicin and curcumin as the cytotoxic drug and chemosensitizer, respectively. The as-prepared TDDS composed of Eth/Eth loading multidrug is an effective means for treating melanoma.
Reference Key
ma2019polyethyleniminenanomedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ma, Linlin;Wang, Xiaoyun;Wu, Jinglei;Zhang, Dongdong;Zhang, Lin;Song, Xinran;Hong, Huoyan;He, Chuanglong;Mo, Xiumei;Wu, Sufang;Kai, Guoyin;Wang, Hongsheng;
Journal nanomedicine (london, england)
Year 2019
DOI
10.2217/nnm-2018-0398
URL
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