cardiovascular magnetic resonance frontiers: tissue characterisation with mapping
Clicks: 152
ID: 217720
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
152 views
25 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #42 of 77 articles by views in annales pharmaceutiques francaises
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The clinical use of cardiovascular magnetic resonance (CMR) imaging has expanded rapidly over the last decade. Its role in cardiac morphological and functional assessment is established, with perfusion and late gadolinium enhancement (LGE) imaging for scar increasingly used in day-to-day clinical decision making. LGE allows a virtual histological assessment of the myocardium, with the pattern of scar suggesting disease aetiology, and the extent of predicting risk. However, even combined, the full range of pathological processes occurring in the myocardium are not interrogated. Mapping is a new frontier where the intrinsic magnetic properties of heart muscle are measured to probe further. T1, T2 and T2* mapping measures the three fundamental tissue relaxation rate constants before contrast, and the extracellular volume (ECV) after contrast. These are displayed in colour, often providing an immediate appreciation of pathology. These parameters are differently sensitive to pathologies. Iron (cardiac siderosis, intramyocardial haemorrhage) makes T1, T2 and T2* fall. T2 also falls with fat infiltration (Fabry disease). T2 increases with oedema (acute infarction, takotsubo cardiomyopathy, myocarditis, rheumatological disease). Native T1 increases with fibrosis, oedema and amyloid. Some of these changes are large (e.g. iron, oedema, amyloid), others more modest (diffuse fibrosis). They can be used to detect early disease, distinguish aetiology and, in some circumstances, guide therapy. In this review, we discuss these processes, illustrating clinical application and future advances.
| Reference Key |
schofield2016southcardiovascular
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Rebecca Schofield;Anish Bhuva;Katia Manacho;James C. Moon |
| Journal | annales pharmaceutiques francaises |
| Year | 2016 |
| DOI |
10.4102/sajr.v20i2.1019
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.