neuroactive steroids in first-episode psychosis: a role for progesterone?

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ID: 217717
2016
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Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p=0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p=0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
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murri2016schizophrenianeuroactive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Martino Belvederi Murri, Flaminia Fanelli, Uberto Pagotto, Elena Bonora, Federico Triolo, Luigi Chiri, Fabio Allegri, Marco Mezzullo, Marco Menchetti, Valeria Mondelli, Carmine Pariante, Domenico Berardi, Ilaria Tarricone
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Journal blood and lymphatic cancer: targets and therapy
Year 2016
DOI
10.1155/2016/1942828
URL
http://dx.doi.org/10.1155/2016/1942828
Keywords
psychiatry

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