neuroactive steroids in first-episode psychosis: a role for progesterone?
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ID: 217717
2016
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Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p=0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p=0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
| Reference Key |
murri2016schizophrenianeuroactive
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| Authors | ;Martino Belvederi Murri;Flaminia Fanelli;Uberto Pagotto;Elena Bonora;Federico Triolo;Luigi Chiri;Fabio Allegri;Marco Mezzullo;Marco Menchetti;Valeria Mondelli;Carmine Pariante;Domenico Berardi;Ilaria Tarricone |
| Journal | blood and lymphatic cancer: targets and therapy |
| Year | 2016 |
| DOI |
10.1155/2016/1942828
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| URL | |
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