dietary flavonoid hyperoside induces apoptosis of activated human lx-2 hepatic stellate cell by suppressing canonical nf-κb signaling
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2016
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Abstract
Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-XL, and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.
| Reference Key |
wang2016biomeddietary
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|---|---|
| Authors | ;Liwen Wang;Zhiwei Yue;Mengzheng Guo;Lianying Fang;Liang Bai;Xinyu Li;Yongqing Tao;Suying Wang;Qiang Liu;Dexian Zhi;Hui Zhao |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2016 |
| DOI |
10.1155/2016/1068528
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