dietary flavonoid hyperoside induces apoptosis of activated human lx-2 hepatic stellate cell by suppressing canonical nf-κb signaling

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ID: 217705
2016
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Abstract
Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-XL, and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.
Reference Key
wang2016biomeddietary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liwen Wang, Zhiwei Yue, Mengzheng Guo, Lianying Fang, Liang Bai, Xinyu Li, Yongqing Tao, Suying Wang, Qiang Liu, Dexian Zhi, Hui Zhao
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Journal spectrochimica acta - part a: molecular and biomolecular spectroscopy
Year 2016
DOI
10.1155/2016/1068528
URL
http://dx.doi.org/10.1155/2016/1068528
Keywords
Medicine

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