a case of poorly differentiated large-cell neuroendocrine carcinoma of the cecum: a rare malignancy, with review of the literature

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ID: 217544
2016
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Abstract
Poorly differentiated neuroendocrine carcinomas (NECs) are rare tumors that can arise anywhere along the gastrointestinal tract. They often present in advanced stage and portend a poor prognosis when compared to adenocarcinomas of the same stage. Characterization of these tumors is best accomplished with tissue biopsy, as peripheral tumor markers commonly used in NECs are of little utility. Therapeutic strategies often involve chemotherapeutic regimens that have been used to treat small-cell lung cancer. Recent studies have shown that programmed death-ligand 1 (PD-L1) expression within poorly differentiated NECs is a poor prognostic indicator. However, PD-L1 expression may represent a possible target for immunotherapy drugs, often called checkpoint inhibitors, such as anti-PD-1 inhibitors.
Reference Key
mertz2016casea Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Andrew T. Mertz;Michelle A. Ojemuyiwa
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2016
DOI
10.1159/000452655
URL
http://www.karger.com/Article/FullText/452655
Keywords
immunotherapy programmed death-ligand 1 Oncology including cancer and carcinogens tumors

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