a herbal formula, cgxii, exerts antihepatofibrotic effect in dimethylnitrosamine-induced sd rat model

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ID: 217406
2016
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Abstract
We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A. iwayomogi, A. xanthioides, and S. miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis. Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly). Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily. DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII. CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents. Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII. Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII. The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection. Administration of CGXII normalized the protein and gene expression levels of these cytokines. Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects.
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kim2016evidence-baseda Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hyo-Seon Kim, Hyeong-Geug Kim, Hye-Won Lee, Sung-Bae Lee, Jin-Seok Lee, Hwi-Jin Im, Won-Yong Kim, Dong-Soo Lee, Chang-Gue Son
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Journal ACS applied materials & interfaces
Year 2016
DOI
10.1155/2016/5093718
URL
http://dx.doi.org/10.1155/2016/5093718
Keywords
Other systems of medicine

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