late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

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ID: 217396
1997
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Abstract
Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non-selective phosphodiesterase (PDE) inhibitors was investigated in mice. Respiratory resistance (Rrs) increased in sensitized BDF1 mice 4-6 h after antigen provocation, whereas no obvious immediate reaction was observed. This reaction was associated with marked airway neutrophilia without significant infiltration of eosinophils. A selective PDE IV inhibitor, T-440 (10-30 mg/kg), and a non-selective PDE inhibitor, theophylline (10 mg/kg), significantly inhibited airway obstruction and neutrophilia when administered orally. An anti-allergic drug, ketotifen (1 mg/kg), caused slight inhibition of airway obstruction, whereas it did not affect airway neutrophilia. These results suggest that neutrophilic inflammation plays a role in the airway obstructive reaction and that PDE has a regulatory role in obstructive airway disease associated with airway inflammation.
Reference Key
kaminuma1997allergologylate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Osamu Kaminuma, Shinya Murakami, Matsunobu Suko, Hideo Kikkawa, Shigeki Matsubara, Wataru Toriumi, Katsuo Ikezawa, Hirokazu Okudaira, Koji Ito
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Journal current drug discovery technologies
Year 1997
DOI
10.2332/allergolint.46.101
URL
http://www.sciencedirect.com/science/article/pii/S1323893015315860
Keywords
mouse airway inflammation neutrophil airway obstruction allergy

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