late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors
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ID: 217396
1997
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Abstract
Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non-selective phosphodiesterase (PDE) inhibitors was investigated in mice. Respiratory resistance (Rrs) increased in sensitized BDF1 mice 4-6 h after antigen provocation, whereas no obvious immediate reaction was observed. This reaction was associated with marked airway neutrophilia without significant infiltration of eosinophils. A selective PDE IV inhibitor, T-440 (10-30 mg/kg), and a non-selective PDE inhibitor, theophylline (10 mg/kg), significantly inhibited airway obstruction and neutrophilia when administered orally. An anti-allergic drug, ketotifen (1 mg/kg), caused slight inhibition of airway obstruction, whereas it did not affect airway neutrophilia. These results suggest that neutrophilic inflammation plays a role in the airway obstructive reaction and that PDE has a regulatory role in obstructive airway disease associated with airway inflammation.
| Reference Key |
kaminuma1997allergologylate
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|---|---|
| Authors | ;Osamu Kaminuma;Shinya Murakami;Matsunobu Suko;Hideo Kikkawa;Shigeki Matsubara;Wataru Toriumi;Katsuo Ikezawa;Hirokazu Okudaira;Koji Ito |
| Journal | current drug discovery technologies |
| Year | 1997 |
| DOI |
10.2332/allergolint.46.101
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| URL | |
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