the role of sonic hedgehog in craniofacial patterning, morphogenesis and cranial neural crest survival

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ID: 217365
2016
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Abstract
Craniofacial defects (CFD) are a significant healthcare problem worldwide. Understanding both the morphogenetic movements which underpin normal facial development, as well as the molecular factors which regulate these processes, forms the cornerstone of future diagnostic, and ultimately, preventative therapies. The soluble morphogen Sonic hedgehog (Shh), a vertebrate orthologue of Drosophila hedgehog, is a key signalling factor in the regulation of craniofacial skeleton development in vertebrates, operating within numerous tissue types in the craniofacial primordia to spatiotemporally regulate the formation of the face and jaws. This review will provide an overview of normal craniofacial skeleton development, and focus specifically on the known roles of Shh in regulating the development and progression of the first pharyngeal arch, which in turn gives rise to both the upper jaw (maxilla) and lower jaw (mandible).
Reference Key
dworkin2016journalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sebastian Dworkin;Yeliz Boglev;Harley Owens;Stephen J. Goldie
Journal journal of counseling psychology
Year 2016
DOI
10.3390/jdb4030024
URL
http://www.mdpi.com/2221-3759/4/3/24
Keywords
development hedgehog mandible maxilla craniofacial

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