an efficient one-pot three-component synthesis of α-amino nitriles via strecker reaction catalysed by bismuth(iii) nitrate
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ID: 217068
2016
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Abstract
A convenient and efficient one-pot method for the synthesis of a variety of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (TMSCN) in the presence of a catalytic amount of Bi(NO3)3 at room temperature in acetonitrile (MeCN) is described. The significant features of this method are simple work-up procedure, inexpensive and non-toxic catalyst, shorter reaction times and excellent product yields. The catalyst Bi(NO3)3 can be reused. The reusability of the catalyst has been studied for the synthesis of various amino nitriles.
| Reference Key |
mansoor2016journalan
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|---|---|
| Authors | ;S. Sheik Mansoor;K. Aswin;K. Logaiya;S.P.N. Sudhan |
| Journal | zaporožskij medicinskij Žurnal |
| Year | 2016 |
| DOI |
10.1016/j.jscs.2012.10.009
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