effect of antibiotic concentration and exposure time on the release of endotoxin by microorganisms

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ID: 216932
2010
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Abstract
Antibiotics represent a key component of treatment for severe bacterial infection. Bacterial lipopolysaccharide from Gram-negative organisms is now well recognized to be a potent microbial toxin that plays a critical role in the initiation of the proinflammatory events that contribute to the pathogenesis of the disease. Pseudomonas aeruginosa, Haemophilus influenza and Escherichia coli were exposed to 0.5 MIC and 5 MIC of Imipenem, Aztreonam, Gentamicin and Polymyxin B for 2 and 5 h. Variable amounts of endotoxin were released after exposing the organism to antibiotic. Aztreonam at a concentration of 0.5 MIC with exposure period 5 h, induced the release of substantial amounts of endotoxin from all organisms and decreased amounts of endotoxin by Gentamicin while Imipenem and Polymyxin B induced the release of negligible values under the same conditions.
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m.2010malaysianeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Alssum, R. M.;Alharby, A.;Omar, H. M. Shair
Journal Journal of developmental origins of health and disease
Year 2010
DOI
DOI not found
URL
http://web.usm.my/mjm/issues/vol6no2/Short1.pdf
Keywords
bacteria infection endotoxin antibiotics neuroinflammatorymicrobiology

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