variation in response of schistosoma mansoni strains to schistosomicides
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ID: 216866
1988
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Abstract
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.
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| Authors | ;Luiz Cândido de Souza Dias;John I. Bruce;Gerald C. Coles |
| Journal | 2017 12th international conference for internet technology and secured transactions, icitst 2017 |
| Year | 1988 |
| DOI |
10.1590/S0036-46651988000200005
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