apo-9′-fucoxanthinone, isolated from sargassum muticum, inhibits cpg-induced inflammatory response by attenuating the mitogen-activated protein kinase pathway

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ID: 216620
2013
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Abstract
Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9′-fucoxanthinone (APO-9′) isolated from S. muticum on pro-inflammatory cytokine production. S. muticum extract (SME) exhibited significant inhibitory effects on pro-inflammatory cytokine production in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). APO-9′ pre-treatment in the CpG DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-α production with IC50 values ranging from 5.31 to 13.79. It exhibited a strong inhibitory effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter activity. APO-9′ pre-treatment exhibited significant inhibition of CpG DNA-induced production of inducible nitric oxide synthase. Taken together, these data suggest that SME and APO-9′ have a significant anti-inflammatory property and warrant further studies concerning the potentials of SME and APO-9′ for medicinal use.
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koh2013marineapo-9-fucoxanthinone, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Young-Sang Koh;Mi-Hee Ko;Jin-Won Hyun;Nam Ho Lee;Hee-Kyoung Kang;Eun-Sook Yoo;Tae-Heon Oh;Sung Chun Kim;Sohyun Kim;Zahid Manzoor;Doobyeong Chae
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2013
DOI
10.3390/md11093272
URL
http://www.mdpi.com/1660-3397/11/9/3272
Keywords
erk1/2 pro-inflammatory cytokine activator protein-1 sargassum muticum inflammationbiology (general)

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