comparison of the effectiveness of three methods of recanalization in a model of the middle cerebral artery: thrombus aspiration via a 4f catheter, thrombus aspiration via the gp thromboaspiration device, and mechanical thrombectomy using the solitaire thrombectomy device
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2011
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Abstract
Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter (n=26), thrombus aspiration via the GP thrombus aspiration device (GPTAD) (n=30), and mechanical thrombectomy via the Solitaire Device (n=30). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s P<.05 Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, P<.05). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo.
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| Reference Key |
tennuci2011strokecomparison
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|---|---|
| Authors | ;Christopher Tennuci;Gillian Pearce;Julian Wong;Sanjeev Nayak;Tom Jones;Frank Lally;Christine Roffe |
| Journal | colloids and surfaces b, biointerfaces |
| Year | 2011 |
| DOI |
10.4061/2011/186424
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| URL | |
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