baicalin inhibits il-17-mediated joint inflammation in murine adjuvant-induced arthritis

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ID: 216112
2013
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Abstract
T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.
Reference Key
yang2013clinicalbaicalin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xue Yang, Ji Yang, Hejian Zou
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Journal Applied Surface Science
Year 2013
DOI
10.1155/2013/268065
URL
http://dx.doi.org/10.1155/2013/268065
Keywords
immunologic diseases allergy

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