validation study methods for estimating odds ratio in 2×2×j tables when exposure is misclassified

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ID: 216096
2013
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Abstract
Background. Misclassification of exposure variables in epidemiologic studies may lead to biased estimation of parameters and loss of power in statistical inferences. In this paper, the inverse matrix method, as an efficient method of the correction of odds ratio for the misclassification of a binary exposure, was generalized to nondifferential misclassification and 2×2×J tables. Methods. Simple estimates for predictive values when misclassification is nondifferential are presented. Using them, we estimated the corrected log odds ratio and its variance for 2×2×J tables, using the inverse matrix method. A two-step weighted likelihood method was also developed. Moreover, we compared the matrix and inverse matrix methods to the maximum likelihood (MLE) method using a simulation study. Results. In all situations, the inverse matrix method proved to be more efficient than the matrix method. Matrix and inverse matrix methods for nondifferential situations are more efficient than differential misclassification. Conclusions. Although MLE is optimal among all of the methods, it is computationally difficult and requires programming. On the other hand, the inverse matrix method with a simple closed-form presents acceptable efficiency.
Reference Key
nouri2013computationalvalidation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bijan Nouri;Najaf Zare;Seyyed Mohammad Taghi Ayatollahi
Journal advanced functional materials
Year 2013
DOI
10.1155/2013/170120
URL
http://dx.doi.org/10.1155/2013/170120
Keywords
medical informatics computer applications to medicine

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