isolation and structural determination of the first 8-epi-type tetrodotoxin analogs from the newt, cynops ensicauda popei, and comparison of tetrodotoxin analogs profiles of this newt and the puffer fish, fugu poecilonotus
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2012
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Abstract
Identification of new tetrodotoxin (TTX) analogs from TTX-possessing animals might provide insight into its biosynthesis and metabolism. In this study, four new analogs, 8-epi-5,6,11-trideoxyTTX, 4,9-anhydro-8-epi-5,6,11-trideoxyTTX, 1-hydroxy-8-epi-5,6,11-trideoxyTTX, and 1-hydroxy-4,4a-anhydro-8-epi-5,6,11-trideoxyTTX, were isolated from the newt, Cynops ensicauda popei, and their structures were determined using spectroscopic methods. These are the first 8-epi-type analogs of TTX that have been found in a natural source. Furthermore, we examined the composition of the TTX analogs in this newt and in the ovary of the puffer fish, Fugu poecilonotus, using LC/MS. The results indicate that TTX and 11-deoxyTTX were present in both sources. However, 6-epiTTX and 8-epi-type analogs were detected only in the newt, while 5,6,11-trideoxyTTX was a specific and major analog in the puffer fish. Such considerable differences among analog compositions might reflect differences in the biosynthesis or metabolism of TTX between these animals.
| Reference Key |
yotsu-yamashita2012marineisolation
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| Authors | ;Mari Yotsu-Yamashita;Yuta Kudo;Takeshi Yasumoto;Keiichi Konoki;Yuko Cho |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2012 |
| DOI |
10.3390/md10030655
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| URL | |
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