Isorhamnetin glycoside isolated from Opuntia ficus-indica (L.) MilI induces apoptosis in human colon cancer cells through mitochondrial damage.

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ID: 21603
2019
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Abstract
This work aimed to evaluate the mechanisms involved in the apoptosis induction of isorhamnetin-3-O-glucosyl-pentoside (IGP) in metastatic human colon cancer cells (HT-29). To achieve this, we assessed phosphatidylserine (PS) exposure, cell membrane disruption, chromatin condensation, cell cycle alterations, mitochondrial damage, ROS production, and caspase-dependence on cell death. Our results showed that IGP induced cell death on HT-29 cells through PS exposure (48%) and membrane permeabilization (30%) as well as nuclear condensation (54%) compared with control cells. Moreover, IGP treatment induced cell cycle arrest in G2/M phase. Bax/Bcl-2 ratio increased and the loss of mitochondrial membrane potential (63%) was observed in IGP-treated cells. Finally, as apoptosis is a caspase-dependent cell death mechanism, we used a pancaspase-inhibitor (Q-VD-OPh) to demonstrate that the cell death induced by IGP was caspase-dependent. Overall these results indicated that IGP induced apoptosis through caspase-dependent mitochondrial damage in HT-29 colon cancer cells.
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antunesricardo2019isorhamnetinchemicobiological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Antunes-Ricardo, Marilena;Hernández-Reyes, Annia;Uscanga-Palomeque, Ashanti C;Rodríguez-Padilla, Cristina;Martínez-Torres, Ana Carolina;Gutiérrez-Uribe, Janet Alejandra;
Journal Chemico-biological interactions
Year 2019
DOI
S0009-2797(18)31699-5
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