comparative antifungal activity of cilofungin (ly121019) against candida species, including evaluation of susceptibility testing method
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1992
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Abstract
The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.
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chagla1992canadiancomparative
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| Authors | ;Abdul H Chagla;John H Hii;Daryl J Hoban;Andrew E Simor;Santiago Ferro;Evelyn Witwicki;Ruby Poon;Donald E Low |
| Journal | computer science |
| Year | 1992 |
| DOI |
10.1155/1992/260839
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