predictive and prognostic value of sprr in patients with primary epithelial ovarian cancer

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ID: 215444
2016
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Abstract
Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated. Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included. sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera. Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen. Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS). Results. There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data. Also the distribution of sPRR in patients and controls was normal. Conclusion. sPRR seems to have no predictive, prognostic, or diagnostic value in EOC. As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected.
Reference Key
kreienbring2016analyticalpredictive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Katrin Kreienbring;Annika Franz;Rolf Richter;Duska Dragun;Harald Heidecke;Ralf Dechend;Dominik N. Muller;Jalid Sehouli;Elena I. Braicu
Journal oriente moderno
Year 2016
DOI
10.1155/2016/6845213
URL
http://dx.doi.org/10.1155/2016/6845213
Keywords
neoplasms Oncology including cancer and carcinogenscytology tumors

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