etiology of end-stage renal disease and arterial stiffness among hemodialysis patients

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2017
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Abstract
Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness among a cohort of hemodialysis patients. Methods. Etiology of ESRD was identified from patients’ medical records and classified as either vascular renal disease, diabetic nephropathy, nondiabetic glomerulopathy, tubular interstitial nephropathy, hereditary nephropathy, or ESRD of unconfirmed etiology. Results. A total of 82 subjects were enrolled. cfPWV was independently associated with the composite of either diabetic nephropathy or vascular renal disease (p=0.022), pulse pressure (p=0.001), and a history of CV events (p=0.025), but not history of hypertension or diabetes mellitus alone. The median cfPWVs in diabetic nephropathy and vascular renal disease were comparable and significantly higher than median cfPWVs in other etiologies of ESRD. Conclusion. The study suggests that the etiology of ESRD is independently associated with arterial stiffness among hemodialysis patients. Furthermore, arterial stiffness was higher among patients who developed renal sequelae of either diabetes mellitus or hypertension as compared with those who have a history of either diabetes mellitus or hypertension alone.
Reference Key
ghoul2017biomedetiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Balsam El Ghoul;Yazan Daaboul;Serge Korjian;Andrew El Alam;Anthony Mansour;Essa Hariri;Salam Samad;Pascale Salameh;Georges Dahdah;Jacques Blacher;Michel E. Safar;Sola Aoun Bahous
Journal spectrochimica acta - part a: molecular and biomolecular spectroscopy
Year 2017
DOI
10.1155/2017/2543262
URL
http://dx.doi.org/10.1155/2017/2543262
Keywords
Medicine

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