glucantime resistant leishmania promastigotes are sensitive to pentostam

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ID: 215088
1992
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Abstract
Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.
Diferentes amostras de Leishmania foram analisadas quanto à susceptibilidade in vitro ao pentostam - uma cepa de L. (V) braziliensis considerada sensível ao glucantime, três cepas (duas L. (V) braziliensis e uma L. (L) amazonensis) consideradas naturalmente resistentes ao glucantime, uma linhagem resistente (L. (V) guyanensis) selecionada in vitro pela exposição em alta concentração de droga. A elevada sensibilidade destas amostras em contraposição à resistência observada para o glucantime sugere existir relação entre a estrutura química e a atividade destes compostos. Estes dados indicam a necessidade de ima avaliação comparativa de atividade clínica do pentostam e do glucantime no tratamento da leishmaniose.
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moreira1992revistaglucantime Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elizabeth Spangler Andrade Moreira;Juliana Becattini Guerra;Maria de Lourdes Petrillo-Peixoto
Journal mobile information systems
Year 1992
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006
Keywords
leishmania growth inhibition tropical medicine

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