obstetrical antiphospholipid syndrome: from the pathogenesis to the clinical and therapeutic implications

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ID: 215062
2013
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Abstract
Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations associated with the presence of antiphospholipid antibodies (aPL) in patient plasma. Obstetrical APS is a complex entity that may affect both mother and fetus throughout the entire pregnancy with high morbidity. Clinical complications are as various as recurrent fetal losses, stillbirth, intrauterine growth restriction (IUGR), and preeclampsia. Pathogenesis of aPL targets trophoblastic cells directly, mainly via proapoptotic, proinflammatory mechanisms, and uncontrolled immunomodulatory responses. Actual first-line treatment is limited to low-dose aspirin (LDA) and low-molecular weight heparin (LMWH) and still failed in 30% of the cases. APS pregnancies should be a major field in obstetrical research, and new therapeutics are still in progress.
Reference Key
marchetti2013clinicalobstetrical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;T. Marchetti;M. Cohen;P. de Moerloose
Journal Applied Surface Science
Year 2013
DOI
10.1155/2013/159124
URL
http://dx.doi.org/10.1155/2013/159124
Keywords
immunologic diseases allergy

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