the blocking on the cathepsin b and fibronectin accumulation in kidney glomeruli of diabetic rats

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ID: 214708
2015
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Abstract
Hyperglycemia results in the activation of tissue angiotensin II. Angiotensin II stimulates the synthesis of ECM proteins and causes a decrease activity of proteolytic enzymes. The aim of this study was to assess the impact of multilevel blocking of the RAAS, cathepsin B activity, and fibronectin accumulation in the glomerular in the rats diabetes model. Sixty male Wistar rats were initially included. Diabetes was induced by intravenous administration of streptozotocin. The animals were randomized to six groups of ten rats in group. Rats in the four groups were treated with inhibitors of the RAAS: enalapril (EN), losartan (LOS), enalapril plus losartan (EN + LOS), and spironolactone (SPIR); another group received dihydralazine (DIH) and the diabetic rats (DM) did not receive any drug. After six weeks, we evaluated blood pressure, 24 h urine collection, and blood for biochemical parameters and kidneys. In this study, fluorometric, ELISA, and immunohistochemical methods were used. Administration of EN + LOS increased activity of cathepsin B in homogenates of glomeruli compared to DM. Losartan treatment resulted in reduction of the ratio kidney weight/body weight compared to untreated diabetic rats. SPIR resulted in the increase activity of cathepsin B in the homogenate of glomeruli. The values of cathepsin B in the plasma of rats in all studied groups were similar and showed no tendency.
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wyczalkowska-tomasik2015internationalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Aleksandra Wyczalkowska-Tomasik;Irena Bartlomiejczyk;Agnieszka Wirkowska;Lukasz Koperski;Barbara Gornicka;Leszek Paczek
Journal zhonghua wei zhong bing ji jiu yi xue
Year 2015
DOI
10.1155/2015/812825
URL
http://dx.doi.org/10.1155/2015/812825
Keywords
clinical endocrinology diseases of the endocrine glands

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