hyperammonemia associated with valproic acid concentrations
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ID: 214696
2014
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Abstract
Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representing β-oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochondria as any other fatty acid. Long-term high-dose VPA therapy or acute VPA overdose induces carnitine depletion, resulting in high levels of ammonia in blood. As a high correlation between salivary valproic acid levels and plasma ultrafiltrate levels was found in humans, saliva becomes a promising monitoring fluid in order to study valproic acid pharmacokinetics and its toxic effect. Extended-release (twice daily) formulations of valproic acid or carnitine supplementation are the proposed two therapeutic strategies in order to reverse hyperammonemia.
| Reference Key |
vzquez2014biomedhyperammonemia
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|---|---|
| Authors | ;Marta Vázquez;Pietro Fagiolino;Cecilia Maldonado;Ismael Olmos;Manuel Ibarra;Silvana Alvariza;Natalia Guevara;Laura Magallanes;Ivette Olano |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2014 |
| DOI |
10.1155/2014/217269
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| URL | |
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