concepts and principles of photodynamic therapy as an alternative antifungal discovery platform
Clicks: 281
ID: 214249
2012
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Star Article
31.0
/100
281 views
63 readers
AI Quality Assessment
Not analyzed
Readership in this journal
StarRanked #326 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 875 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due to a combination of slow diagnosis and the existence of relatively few classes of available and effective antifungal drugs. Therefore systemic fungal infections result in high attributable mortality. There is an urgent need to pursue and deploy novel and effective alternative anti-fungal countermeasures. Photodynamic therapy was established as a successful modality for malignancies and age-related macular degeneration but photodynamic inactivation has only recently been intensively investigated as an alternative antimicrobial discovery and development platform. The concept of photodynamic inactivation requires microbial exposure to either exogenous or endogenous photosensitizer molecules, followed by visible light energy, typically wavelengths in the red/near infrared region that cause the excitation of the photosensitizers resulting in the production of singlet oxygen and other reactive oxygen species that react with intracellular components, and consequently produce cell inactivation and death. Anti-fungal photodynamic therapy is an area of increasing interest, as research is advancing i) to identify the photochemical and photophysical mechanisms involved in photoinactivation; ii) to develop potent and clinically compatible photosensitizers; iii) to understand how photoinactivation is affected by key microbial phenotypic elements multidrug resistance and efflux, virulence and pathogenesis determinants, and formation of biofilms; iv) to explore novel photosensitizer delivery platforms and v) to identify photoinactivation applications beyond the clinical setting such as environmental disinfectants.
| Reference Key |
etegos2012frontiersconcepts
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;George eTegos;George eTegos;George eTegos;Tianhong eDai;Tianhong eDai;Beth B Fuchs;Jeffrey J Coleman;Renato Araujo Prates;Christos eAstrakas;Tyler G St Denis;Tyler G St Denis;Martha S Ribeiro;Eleftherios eMylonakis;Michael R Hamblin;Michael R Hamblin;Michael R Hamblin |
| Journal | journal of magnetic resonance (san diego, calif : 1997) |
| Year | 2012 |
| DOI |
10.3389/fmicb.2012.00120
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.