left atrial appendage closure in atrial fibrillation: a world without anticoagulation?

Clicks: 149
ID: 214204
2011
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Abstract
Atrial Fibrillation (AF) is a common arrhythmia with an incidence that is as high as 10% in the elderly population. Given the large proportion of strokes caused by AF as well as the associated morbidity and mortality, reducing stroke burden is the most important part of AF management. While warfarin significantly reduces the risk of AF-related stroke, perceived bleeding risks and compliance limit its widespread use in the high-risk AF population. The left atrial appendage is believed to be the “culprit” for thrombogenesis in nonvalvular AF and is a new therapeutic target for stroke prevention. The purpose of this review is to explore the evolving field of percutaneous LAA occlusion. After briefly highlighting the risk of stroke with AF, problems with warfarin, and the role of the LAA in clot formation, this article discusses the feasibility and efficacy of various devices which have been developed for percutaneous LAA occlusion.
Reference Key
contractor2011cardiologyleft Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tahmeed Contractor;Atul Khasnis
Journal acta crystallographica section c, structural chemistry
Year 2011
DOI
10.4061/2011/752808
URL
http://dx.doi.org/10.4061/2011/752808
Keywords
Diseases of the circulatory (Cardiovascular) system

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