subacute cerebellar degeneration due to a paraneoplastic phenomenon associated with metastatic merkel cell carcinoma: a case report

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ID: 213374
2017
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Abstract
Purpose: The aim of this article is to illustrate the diagnostic challenges and management of paraneoplastic neurological syndromes in Merkel cell carcinoma. Materials and Methods: We describe a previously functionally independent 85-year-old woman who presented with subacute onset of dizziness and gait ataxia in the setting of metastatic Merkel cell carcinoma. Results: Diagnosis was made on biopsy after positron emission tomography imaging revealed increased metabolic activity in 2 left inguinofemoral lymph nodes. Cerebrospinal fluid analysis was positive for anti-Hu on subsequent admission. Her functional status improved with methylprednisolone treatment and radiotherapy. Conclusion: The case highlights the challenge of the evaluation of patients who present with progressive cerebellar signs and the need to consider a paraneoplastic syndrome, especially in the setting of previous malignancy.
Reference Key
sharobeam2017casesubacute Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Angelos Sharobeam;Jason Ray;Juliana Dong;Victor Chong
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2017
DOI
10.1159/000479731
URL
http://www.karger.com/Article/FullText/479731
Keywords
metastasis merkel cell carcinoma Oncology including cancer and carcinogens tumors

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