rapid disease progression of liver metastases following resection in a liver-transplanted patient with probable lynch syndrome – a case report and review of the literature

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ID: 213329
2017
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Abstract
Solid organ transplantation provides life-saving therapy for patients with end-stage organ disease, and its outcomes have been improving dramatically over the past few decades. However, substantial morbidity results from chronic immunosuppressive therapy administered to prevent graft rejection. It predisposes patients to several life-threatening complications, such as opportunistic microbial infections and the development of different types of cancers. Here, we presented the case of a young man with probable Lynch syndrome, who developed an aggressive colon carcinoma after long-term immunosuppressive therapy due to a prior liver transplantation. Based on this case report, we attempt to find an answer to the question about the risk of cancer development or recurrence in patients with familial syndromes receiving long-term immunosuppressive therapy and to find out how it can be minimized. Answering these questions is particularly important, given the facts that disease course is substantially more aggressive among transplanted patients and that prognosis is poor due to lack of immunocompetence, especially in the setting of Lynch syndrome.
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wassano2017caserapid Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Noelle Suemi Wassano;Francisco  Sergi;Gustavo Ferro;Tércio Genzini;Renata D’Alpino Peixoto
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2017
DOI
10.1159/000460241
URL
http://www.karger.com/Article/FullText/460241
Keywords
resection Oncology including cancer and carcinogens tumors

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