hypothalamic mitochondrial dysfunction as a target in obesity and metabolic disease

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ID: 212803
2018
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Abstract
Mitochondria are important organelles for the adaptation to energy demand that play a central role in bioenergetics metabolism. The mitochondrial architecture and mitochondrial machinery exhibits a high degree of adaptation in relation to nutrient availability. On the other hand, its disruption markedly affects energy homeostasis. The brain, more specifically the hypothalamus, is the main hub that controls energy homeostasis. Nevertheless, until now, almost all studies in relation to mitochondrial dysfunction and energy metabolism have focused in peripheral tissues like brown adipose tissue, muscle, and pancreas. In this review, we highlight the relevance of the hypothalamus and the influence on mitochondrial machinery in its function as well as its consequences in terms of alterations in both energy and metabolic homeostasis.
Reference Key
cunarro2018frontiershypothalamic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Juan Cunarro;Juan Cunarro;Sabela Casado;Javier Lugilde;Sulay Tovar;Sulay Tovar
Journal aip advances
Year 2018
DOI
10.3389/fendo.2018.00283
URL
https://www.frontiersin.org/article/10.3389/fendo.2018.00283/full
Keywords
obesity treatment mitochondria hypothalamus clinical endocrinology glucosediseases of the endocrine glands

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