ephrin regulation of palate development
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ID: 212678
2012
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Abstract
Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although mechanistic studies of palate growth and fusion have focused on growth factors such at Transforming Growth Factor ß-3 (Tgfß3), recent studies have revealed that the ephrin family of membrane bound ligands and their receptors, the Ephs, play central roles in palatal morphogenesis, growth, and fusion. In this mini-review, we will discuss the recent findings by our group and others on the functions of ephrins in palatal development.
| Reference Key |
benson2012frontiersephrin
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|---|---|
| Authors | ;M. Douglas Benson;Maria J. Serrano |
| Journal | Journal of clinical and experimental dentistry |
| Year | 2012 |
| DOI |
10.3389/fphys.2012.00376
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| URL | |
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