evidence for contribution of cd4+cd25+ regulatory t cells in maintaining immune tolerance to human factor ix following perinatal adenovirus vector delivery
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ID: 212634
2015
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Abstract
Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-term tolerance of hFIX was robust in the face of immune challenge with hFIX protein and adjuvant but was eliminated by simultaneous administration of anti-CD25+ antibody. Naive irradiated BALB/c mice which had received lymphocytes from donors immunised with hFIX developed anti-hFIX antibodies upon immune challenge. Cotransplantation with CD4+CD25+ cells isolated from neonatally tolerized donors decreased the antibody response. In contrast, cotransplantation with CD4+CD25− cells isolated from the same donors increased the antibody response. These data provide evidence that immune tolerance following perinatal gene transfer is maintained by a CD4+CD25+ regulatory population.
| Reference Key |
nivsarkar2015journalevidence
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|---|---|
| Authors | ;Megha S. Nivsarkar;Suzanne M. K. Buckley;Alan L. Parker;Dany Perocheau;Tristan R. McKay;Ahad A. Rahim;Steven J. Howe;Simon N. Waddington |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2015 |
| DOI |
10.1155/2015/397879
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| URL | |
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