viral evasion of natural killer cell activation

Clicks: 240
ID: 212574
2016
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Ranked #173 of 245 articles by views in International journal of pharmaceutics

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Abstract
Natural killer (NK) cells play a key role in antiviral innate defenses because of their abilities to kill infected cells and secrete regulatory cytokines. Additionally, NK cells exhibit adaptive memory-like antigen-specific responses, which represent a novel antiviral NK cell defense mechanism. Viruses have evolved various strategies to evade the recognition and destruction by NK cells through the downregulation of the NK cell activating receptors. Here, we review the recent findings on viral evasion of NK cells via the impairment of NK cell-activating receptors and ligands, which provide new insights on the relationship between NK cells and viral actions during persistent viral infections.
Reference Key
ma2016virusesviral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yi Ma;Xiaojuan Li;Ersheng Kuang
Journal International journal of pharmaceutics
Year 2016
DOI
10.3390/v8040095
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