the transcriptional repressor, mtrr, of the mtrcde efflux pump operon of neisseria gonorrhoeae can also serve as an activator of “off target” gene (glne) expression

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ID: 212571
2015
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Abstract
MtrR is a well-characterized repressor of the Neisseria gonorrhoeae mtrCDE efflux pump operon. However, results from a previous transcriptional profiling study suggested that MtrR also represses or activates expression of at least sixty genes outside of the mtr locus. Evidence that MtrR can directly repress so-called “off target” genes has previously been reported; in particular, MtrR was shown to directly repress glnA, which encodes glutamine synthetase. In contrast, evidence for the ability of MtrR to directly activate expression of gonococcal genes has been lacking; herein, we provide such evidence. We now report that MtrR has the ability to directly activate expression of glnE, which encodes the dual functional adenyltransferase/deadenylase enzyme GlnE that modifies GlnA resulting in regulation of its role in glutamine biosynthesis. With its capacity to repress expression of glnA, the results presented herein emphasize the diverse and often opposing regulatory properties of MtrR that likely contributes to the overall physiology and metabolism of N. gonorrhoeae.
Reference Key
johnson2015antibioticsthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Paul J. T. Johnson;William M. Shafer
Journal derecho pucp
Year 2015
DOI
10.3390/antibiotics4020188
URL
http://www.mdpi.com/2079-6382/4/2/188
Keywords
neisseria gonorrhoeae pharmacology

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