the effect of renal stones on serum adenosine aminohydrolase and amp-aminohydrolase in malaysia
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ID: 211795
2015
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Abstract
Objective: To verify possible associations between adenosine aminohydrolase (ADA) and AMP-aminohydrolase (AMPDA) to E3 SUMO-protein ligase NSE2 (NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group.
Methods: A total of 60 renal stones patients and 50 control were enrolled in a case–control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ELISA.
Results: Serum ADA, AMPDA and specific activity of enzymes showed significant decrease (P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a significant increase (P < 0.01 and P < 0.05, respectively) in patients compared to control group.
Conclusions: The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inflammation disorders in the patients with kidney stones.
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| Reference Key |
yusof2015asianthe
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|---|---|
| Authors | ;Faridah Yusof;Atheer Awad Mehde;Wesen Adel Mehdi;Hamid Ghazali;Azlina Abd Rahman |
| Journal | Organic letters |
| Year | 2015 |
| DOI |
10.1016/j.apjtb.2015.04.003
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| URL | |
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