persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves
Clicks: 295
ID: 211590
2012
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
295 views
50 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #154 of 461 articles by views in Journal of clinical and experimental dentistry
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 461 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Clusters of ryanodine receptors within atrial myocytes are confined to spatially separated layers. In many species, these layers are not juxtaposed by invaginations of the plasma membrane, so that calcium-induced-calcium signals rely on centripetal propagation rather than voltage-synchronised channel openings to invade the interior of the cell and trigger contraction. The combination of this specific cellular geometry and dynamics of calcium release can lead to novel autonomous spatio-temporal waves, and in particular ping waves. These are waves of calcium release activity that spread as counter-rotating sectors of elevated calcium within a single layer of ryanodine receptors, and can seed further longitudinal calcium waves. Here we show, using a computational model, that these calcium waves can dominate the response of a cell to electrical pacing and hence are pro-arrhythmic. This highlights the importance of modelling internal cellular structures when investigating mechanisms of cardiac dysfunction such as atrial arrhythmia.
| Reference Key |
ethul2012frontierspersistence
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Rüdiger eThul;Stephen eCoombes;Martin D Bootman;Martin D Bootman |
| Journal | Journal of clinical and experimental dentistry |
| Year | 2012 |
| DOI |
10.3389/fphys.2012.00279
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.