glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation

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ID: 211584
2017
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Abstract
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system. While typical IgSF CAMs are transmembrane molecules, this superfamily also includes CAMs, which do not possess transmembrane and intracellular domains and are instead attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. In this review, we focus on the role GPI-anchored IgSF CAMs have as signal transducers and ligands in neurons, and discuss their functions in regulation of neuronal development, synapse formation, synaptic plasticity, learning, and behavior. We also review the links between GPI-anchored IgSF CAMs and brain disorders.
Reference Key
tan2017frontiersglycosylphosphatidylinositol-anchored Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rui P. A. Tan;Iryna Leshchyns’ka;Vladimir Sytnyk
Journal international journal of nanomedicine
Year 2017
DOI
10.3389/fnmol.2017.00378
URL
http://journal.frontiersin.org/article/10.3389/fnmol.2017.00378/full
Keywords
cell adhesion molecules neuropsychiatry biological psychiatry synaptic plasticity (ltp/ltd)neurosciences

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