mechanisms behind functional avidity maturation in t cells
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2012
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Abstract
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.
| Reference Key |
essen2012clinicalmechanisms
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|---|---|
| Authors | ;Marina Rode von Essen;Martin Kongsbak;Carsten Geisler |
| Journal | Applied Surface Science |
| Year | 2012 |
| DOI |
10.1155/2012/163453
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| URL | |
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