Ventral Hippocampus Modulates Anxiety-like Behavior in Male but Not Female C57BL/6 J Mice.

Clicks: 363
ID: 21108
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #5 of 21 articles by views in neuroscience

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Remarkable sex difference has been observed in emotional processing including anxiety. The hippocampus, its ventral pole in particular, modulates anxiety-like behavior in rodents. However, most researches have been performed in male animals only, leaving hippocampal modulation of anxiety in females poorly defined. In the present study, we showed that excitotoxic lesioning of the ventral hippocampus with ibotenic acid produced anxiolytic effects in three behavioral tests (novelty-suppressed feeding, marble burying, and elevated-plus maze) in male but not female C57BL/6 J mice. Locomotion in the open field remained similar after lesioning in either sex. More c-Fos-positive neurons were observed in the ventral hippocampus in male than in female mice after exploration in an elevated plus-maze, indicating stronger enrollment of this region in anxiety-like behavior in males. These results reveal significant biological sex difference in ventral hippocampal modulation on anxiety in mice and provide a new sight for anxiety modulation and hippocampal function.
Reference Key
wang2019ventralneuroscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Cheng;Zhang, Yu;Shao, Shan;Cui, Shuang;Wan, You;Yi, Ming;
Journal neuroscience
Year 2019
DOI
S0306-4522(19)30605-0
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.