highly efficient transition metal-free coupling of acid chlorides with terminal alkynes in [bmim]br: a rapid route to access ynones using mgcl2

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ID: 210853
2018
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Abstract
A simple, mild, highly efficient and transition metal-free protocol for synthesis of ynones in an ionic liquid is described. In this approach, the coupling reaction of different acid chlorides with terminal alkynes was efficiently carried out using 0.05 mol% MgCl2 in the presence of triethylamine in [bmim]Br at room temperature to afford the corresponding ynones in good to excellent yields. This method is highly efficient for various acid chlorides and alkynes including aliphatic, aromatic, and heteroaromatic substrates bearing different functional groups. The influence of some parameters in this reaction including type of ionic liquid, base and catalyst has been discussed.
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rad2018journalhighly Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mohammad Navid Soltani Rad
Journal zaporožskij medicinskij Žurnal
Year 2018
DOI
10.1016/j.jscs.2016.06.001
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