polysaccharide extracted from laminaria japonica delays intrinsic skin aging in mice
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ID: 210826
2016
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Abstract
This study aimed to determine the effect of topically applied Laminaria polysaccharide (LP) on skin aging. We applied ointment containing LP (10, 25, and 50 μg/g) or vitamin E (10 μg/g) to the dorsal skin of aging mice for 12 months and young control mice for 4 weeks. Electron microscopy analysis of skin samples revealed that LP increased dermal thickness and skin collagen content. Tissue inhibitor of metalloprotease- (TIMP-) 1 expression was upregulated while that of matrix metalloproteinase- (MMP-) 1 was downregulated in skin tissue of LP-treated as compared to untreated aging mice. Additionally, phosphorylation of c-Jun N-terminal kinase (JNK) and p38 was higher in aging skin than in young skin, while LP treatment suppressed phospho-JNK expression. LP application also enhanced the expression of antioxidative enzymes in skin tissue, causing a decrease in malondialdehyde levels and increases in superoxide dismutase, catalase, and glutathione peroxidase levels relative to those in untreated aging mice. These results indicate that LP inhibits MMP-1 expression by preventing oxidative stress and JNK phosphorylation, thereby delaying skin collagen breakdown during aging.
| Reference Key |
hu2016evidence-basedpolysaccharide
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|---|---|
| Authors | ;Longyuan Hu;Jia Tan;Xiaomei Yang;Haitao Tan;Xiaozhen Xu;Manhang You;Wu Qin;Liangzhao Huang;Siqi Li;Manqiu Mo;Huifen Wei;Jing Li;Jiyong Tan |
| Journal | ACS applied materials & interfaces |
| Year | 2016 |
| DOI |
10.1155/2016/5137386
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| URL | |
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