a systematic review and meta-analysis of the funtional mri investigation of motor neuron disease
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ID: 210789
2015
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Abstract
Background: To assess the use of functional magnetic resonance imaging (fMRI) in motor neuron disease (MND), a systematic review and voxelwise meta-analysis of studies comparing brain activity in patients with MND and in healthy controls (HCs) was conducted to identify common findings across studies.Methods: A search for related papers published in English and Chinese was performed in Ovid Medline, Pubmed and Embase database. Voxelwise meta-analysis was performed using signed differential mapping.Results: The findings from 55 fMRI studies on MND were tabulated, and some common findings were discussed in further details. Conclusions: These findings are preliminary, sometimes even contradictory, and do not allow a complete understanding of the functional alterations in MND. However, we documented reliable findings that MND is not confined to the motor system, but is a multisystem disorder involving extra-motor cortex areas, causing cognitive dysfunction and deficits in socioemotional and sensory processing pathways.
| Reference Key |
eshen2015frontiersa
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|---|---|
| Authors | ;Dongchao eShen;Liying eCui;Liying eCui;Bo eCui;Jia eFang;Dawei eLi;Junfang eMa |
| Journal | journal of photochemistry and photobiology a: chemistry |
| Year | 2015 |
| DOI |
10.3389/fneur.2015.00246
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| URL | |
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