gastroretentive microballoons of metformin: formulation development and characterization

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ID: 210697
2011
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Abstract
The present study involves preparation and evaluation of floating microballoons with metformin as model drug for prolongation of gastric residence time. The microballoons were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microballoons were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of stirring rate during preparation, polymer concentration, solvent composition and dissolution medium on the size of microballoons, and drug release were also observed. The prepared microballoons exhibited prolonged drug release (8 hours) and remained buoyant for >10 hours. The mean particle size increased and the drug release rate decreased at higher polymer concentration. No significant effect of the stirring rate during preparation on drug release was observed. In vitro studies demonstrated diffusion-controlled drug release from the microballoons.
Reference Key
yadav2011journalgastroretentive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Akash Yadav;Dinesh Kumar Jain
Journal solid state communications
Year 2011
DOI
10.4103/2231-4040.79806
URL
http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=1;spage=51;epage=55;aulast=Yadav
Keywords
in vitro release pharmacologypharmacy and materia medica

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